The gene for autosomal dominant spinocerebellar ataxia (SCA1) maps centromeric to D6S89 and shows no recombination, in nine large kindreds, with a dinucleotide repeat at the AM10 locus. [electronic resource]
Producer: 19930809Description: 391-400 p. digitalISSN:- 0002-9297
- Adult
- Alleles
- Base Sequence
- Centromere
- Child
- Chromosome Mapping -- methods
- Chromosomes, Human, Pair 6
- Cloning, Molecular
- Genetic Linkage
- Genetic Markers
- Humans
- Lod Score
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid
- Sequence Analysis, DNA
- Spinocerebellar Degenerations -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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