Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. [electronic resource]
Producer: 19930330Description: 1057-64 p. digitalISSN:- 0270-6474
- Aging -- physiology
- Animals
- Azepines -- pharmacology
- Biogenic Amines -- pharmacology
- Brain -- drug effects
- Cataplexy -- chemically induced
- Chromosome Mapping
- Crosses, Genetic
- Dog Diseases -- genetics
- Dogs
- Dopamine Agents -- pharmacology
- Ergolines -- pharmacology
- Female
- Genes, Recessive
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Male
- Narcolepsy -- genetics
- Parasympathomimetics -- pharmacology
- Pedigree
- Physostigmine -- pharmacology
- Prazosin -- pharmacology
- Quinpirole
- Sleep -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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