An in-frame insertion into the Sindbis virus 6K gene leads to defective proteolytic processing of the virus glycoproteins, a trans-dominant negative inhibition of normal virus formation, and interference in virus shut off of host-cell protein synthesis. [electronic resource]
Producer: 19930323Description: 424-32 p. digitalISSN:- 0042-6822
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Chick Embryo
- Cricetinae
- Culicidae
- Genes, Viral -- genetics
- Glycoproteins -- genetics
- Molecular Sequence Data
- Mutagenesis, Insertional
- Protein Biosynthesis
- Protein Processing, Post-Translational -- genetics
- Sindbis Virus -- genetics
- Viral Proteins -- genetics
- Virion -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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