Competitive inhibition of human liver microsomal cytochrome P450 3A-dependent steroid 6 beta-hydroxylation activity by cyclophosphamide and ifosfamide in vitro. [electronic resource]
Producer: 19940928Description: 645-9 p. digitalISSN:- 0022-3565
- Acrolein -- metabolism
- Animals
- Binding, Competitive
- Cyclophosphamide -- pharmacology
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Humans
- Ifosfamide -- pharmacology
- Microsomes, Liver -- drug effects
- Mixed Function Oxygenases -- antagonists & inhibitors
- NADP -- metabolism
- Rats
- Rats, Wistar
- Steroid Hydroxylases -- metabolism
- Testosterone -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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