Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine. [electronic resource]
Producer: 19950414Description: 1160-9 p. digitalISSN:- 0022-3565
- Adrenergic Uptake Inhibitors -- pharmacology
- Adrenergic alpha-2 Receptor Antagonists
- Animals
- Antidepressive Agents -- pharmacology
- Behavior, Animal -- drug effects
- Blood Pressure -- drug effects
- Clonidine -- pharmacology
- Guinea Pigs
- Heart Rate -- drug effects
- Hippocampus -- metabolism
- In Vitro Techniques
- Male
- Motor Activity -- drug effects
- Mydriasis -- chemically induced
- Neurons -- metabolism
- Olfactory Bulb -- physiology
- Pyrrolidines -- pharmacology
- Rabbits
- Radioligand Assay
- Rats
- Rats, Sprague-Dawley
- Synaptosomes -- metabolism
- Tyramine -- analogs & derivatives
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Publication Type: Journal Article
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