Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. [electronic resource]
Producer: 19950414Description: 5057-64 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Binding Sites
- Crystallography, X-Ray
- Drug Resistance
- Enzyme Stability
- Genetic Variation
- Humans
- Hydrogen-Ion Concentration
- Kinetics
- Leucine
- Methotrexate -- pharmacology
- Models, Molecular
- Mutagenesis, Site-Directed
- NADP -- metabolism
- Point Mutation
- Protein Conformation
- Recombinant Proteins -- chemistry
- Tetrahydrofolate Dehydrogenase -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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