A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. [electronic resource]
Producer: 19950307Description: 434-9 p. digitalISSN:- 0028-1298
- Alleles
- Amino Acid Sequence
- Computer Simulation
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System -- genetics
- Exons
- Genotype
- Histidine -- metabolism
- Humans
- Mixed Function Oxygenases -- genetics
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Proline -- metabolism
- Sequence Analysis
- Sparteine -- metabolism
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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