Molecular modeling and site-directed mutagenesis of an anti-phosphotyrosine antibody predicts the combining site and allows the detection of higher affinity interactions. [electronic resource]
Producer: 19931208Description: 661-8 p. digitalISSN:- 0269-2139
- Amino Acid Sequence
- Antibodies, Monoclonal -- chemistry
- Antigen-Antibody Reactions
- Binding Sites, Antibody
- Blotting, Western
- Computer Simulation
- Crystallography, X-Ray
- Enzyme-Linked Immunosorbent Assay
- Immunoglobulin Fab Fragments -- chemistry
- Immunoglobulin Heavy Chains -- chemistry
- Immunoglobulin Light Chains -- chemistry
- Immunoglobulin Variable Region -- chemistry
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phosphotyrosine
- Polymerase Chain Reaction
- Protein Conformation
- Sequence Alignment
- Sequence Homology, Amino Acid
- Templates, Genetic
- Tyrosine -- analogs & derivatives
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Publication Type: Comparative Study; Journal Article
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