BCR/ABL oncoprotein-targeted antitumor activity of antisense oligodeoxynucleotides complementary to bcr/abl mRNA and herbimycin A, an antagonist of protein tyrosine kinase: inhibitory effects on in vitro growth of Ph1-positive leukemia cells and BCR/ABL oncoprotein-associated transformed cells. [electronic resource]
Producer: 19931208Description: 307-16 p. digitalISSN:- 1042-8194
- Antibiotics, Antineoplastic -- pharmacology
- Base Sequence
- Benzoquinones
- Cell Division -- drug effects
- DNA, Antisense -- therapeutic use
- Dose-Response Relationship, Drug
- Fusion Proteins, bcr-abl -- antagonists & inhibitors
- Humans
- Lactams, Macrocyclic
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Molecular Sequence Data
- Neoplasm Proteins -- antagonists & inhibitors
- Philadelphia Chromosome
- Polymerase Chain Reaction
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Quinones -- pharmacology
- RNA-Directed DNA Polymerase
- Rifabutin -- analogs & derivatives
- Tumor Cells, Cultured -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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