Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. [electronic resource]
Producer: 19931112Description: 1736-44 p. digitalISSN:- 0021-9738
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- DNA Primers
- Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology
- Humans
- Interleukin-3 -- pharmacology
- Leukemia, Mast-Cell -- genetics
- Mice
- Molecular Sequence Data
- Phosphotyrosine
- Point Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Mas
- Proto-Oncogene Proteins -- biosynthesis
- Proto-Oncogene Proteins c-kit
- Proto-Oncogenes
- Receptor Protein-Tyrosine Kinases -- biosynthesis
- Receptors, Colony-Stimulating Factor -- biosynthesis
- Recombinant Proteins -- pharmacology
- Transfection
- Tumor Cells, Cultured
- Tyrosine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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