Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites. [electronic resource]
Producer: 19951204Description: 24216-21 p. digitalISSN:- 0021-9258
- Animals
- Base Sequence
- Binding Sites
- DNA -- genetics
- DNA Primers
- DNA-Binding Proteins -- isolation & purification
- Gene Expression
- HeLa Cells
- Hominidae -- genetics
- Humans
- Liver Neoplasms
- Liver Neoplasms, Experimental
- Models, Structural
- Molecular Sequence Data
- Molecular Weight
- Nucleic Acid Conformation
- Point Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Protein C -- genetics
- Protein C Deficiency
- Recombinant Proteins -- isolation & purification
- Transcription Factors -- isolation & purification
- Transcription, Genetic
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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