The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo. [electronic resource]
Producer: 19950621Description: 15-25 p. digitalISSN:- 1043-4666
- Animals
- Antibodies, Monoclonal -- immunology
- Blood Coagulation Factors -- biosynthesis
- Cachexia -- physiopathology
- Cell Adhesion -- drug effects
- Cell Adhesion Molecules -- biosynthesis
- Cell Division -- drug effects
- Cells, Cultured
- E-Selectin
- Endothelium, Vascular -- drug effects
- Fibroblasts -- drug effects
- Gene Expression Regulation -- drug effects
- Humans
- Infliximab
- Intercellular Adhesion Molecule-1 -- biosynthesis
- Interleukin-6 -- metabolism
- Mice
- Mice, Transgenic
- Neutralization Tests
- Neutrophils -- drug effects
- Recombinant Fusion Proteins -- immunology
- Recombinant Proteins -- pharmacology
- Respiratory Burst -- drug effects
- Thromboplastin
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
- Umbilical Veins
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Publication Type: Journal Article
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