Enzymatic properties of two mutants of reverse transcriptase of human immunodeficiency virus type 1 (tyrosine 181-->isoleucine and tyrosine 188-->leucine), resistant to nonnucleoside inhibitors. [electronic resource]
Producer: 19950209Description: 939-46 p. digitalISSN:- 0889-2229
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Catalysis
- DNA, Viral -- biosynthesis
- Deoxyguanine Nucleotides -- pharmacology
- Dideoxynucleotides
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1 -- drug effects
- Hot Temperature
- Humans
- Kinetics
- Molecular Sequence Data
- Mutation -- physiology
- Nevirapine
- Phenanthrolines -- pharmacology
- Pyridines -- pharmacology
- RNA-Directed DNA Polymerase -- chemistry
- Reverse Transcriptase Inhibitors
- Ribonuclease H -- metabolism
- Templates, Genetic
- Thymine Nucleotides -- pharmacology
- Tyrosine -- physiology
- Zidovudine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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