Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase. [electronic resource]
Producer: 19880304Description: 145-52 p. digitalISSN:- 0893-2751
- Aminobutyrates
- Aminopterin -- analogs & derivatives
- Animals
- Cell Division -- drug effects
- Folic Acid Antagonists -- chemical synthesis
- Growth Inhibitors
- Leukemia L1210 -- enzymology
- Liver -- enzymology
- Methotrexate -- analogs & derivatives
- Mice
- Ornithine -- analogs & derivatives
- Peptide Synthases -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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