Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes. [electronic resource]
Producer: 20210524Description: 844-855 p. digitalISSN:- 1532-6535
- Cell Culture Techniques
- Cells, Cultured
- Constitutive Androstane Receptor
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inducers -- pharmacology
- Drug Evaluation, Preclinical
- Drug Interactions
- ErbB Receptors -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Hepatocytes -- drug effects
- Humans
- Phosphorylation
- Pregnane X Receptor -- drug effects
- Receptors, Cytoplasmic and Nuclear -- drug effects
- Signal Transduction
- Spheroids, Cellular
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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