SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. [electronic resource]
Producer: 20210709Description: 341-364 p. digitalISSN:- 2352-345X
- Acetylation
- Adult
- Aged
- Animals
- Cell Line
- Female
- Gene Expression Regulation
- Gene Knockdown Techniques
- Hepatic Stellate Cells -- pathology
- Humans
- Liver -- cytology
- Liver Cirrhosis -- genetics
- Male
- Mice
- Mice, Knockout
- Middle Aged
- Mutation
- Non-alcoholic Fatty Liver Disease -- genetics
- Primary Cell Culture
- Sirtuins -- deficiency
- Smad3 Protein -- genetics
- Transcriptional Activation
- Transforming Growth Factor beta1 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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