The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. [electronic resource]
Producer: 20210407Description: 4052-4064.e7 p. digitalISSN:- 2211-1247
- Animals
- Disease Resistance
- Disease Susceptibility
- Genetic Variation
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Leishmania donovani -- physiology
- Leishmaniasis, Visceral -- metabolism
- Lipids -- biosynthesis
- Lipogenesis
- Macrophages -- parasitology
- Membrane Proteins -- metabolism
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mitochondrial Proteins -- metabolism
- Myeloid Cells -- metabolism
- Signal Transduction
- Sterol Regulatory Element Binding Protein 1 -- metabolism
- TOR Serine-Threonine Kinases -- metabolism
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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