Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. [electronic resource]
Producer: 20200626Description: 408-417 p. digitalISSN:- 1546-1718
- Adaptation, Physiological -- genetics
- Animals
- Biological Evolution
- CRISPR-Cas Systems -- genetics
- Cell Line
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- genetics
- Environment
- Genetic Fitness -- genetics
- Genetic Pleiotropy -- genetics
- HEK293 Cells
- HL-60 Cells
- Humans
- Mice
- Neoplasms -- genetics
- Nuclear Proteins -- genetics
- Phenotype
- Quantitative Trait Loci -- genetics
- Transcription Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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