Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring. [electronic resource]
Producer: 20210224Description: 103755 p. digitalISSN:- 1090-2120
- Antineoplastic Agents -- chemical synthesis
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- Colchicine -- chemical synthesis
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Humans
- Ligands
- Molecular Structure
- Polymerization -- drug effects
- Pyridines -- chemistry
- Solubility
- Structure-Activity Relationship
- Tubulin -- metabolism
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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