Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition. [electronic resource]
Producer: 20200924Description: 931-940 p. digitalISSN:- 1477-0539
- Animals
- Blood Glucose -- metabolism
- Cyclization
- Density Functional Theory
- Enzyme Inhibitors -- pharmacology
- Glucose -- metabolism
- Glycogen -- metabolism
- Glycogen Phosphorylase -- antagonists & inhibitors
- Hepatocytes -- drug effects
- Humans
- Hypoglycemic Agents -- chemical synthesis
- Inhibitory Concentration 50
- Kinetics
- Lactones -- chemical synthesis
- Oxidation-Reduction
- Rats, Zucker
- Spiro Compounds -- chemical synthesis
- Stereoisomerism
- Temperature
- Thiazoles -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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