SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. [electronic resource]
Producer: 20210902Description: 1949-1973 p. digitalISSN:- 1554-8635
- Adaptor Proteins, Signal Transducing -- metabolism
- Animals
- Autophagy -- genetics
- Fatty Acids -- toxicity
- Fibroblasts -- metabolism
- Hepatocytes -- drug effects
- Humans
- Kelch-Like ECH-Associated Protein 1 -- drug effects
- Liver -- drug effects
- Mice, Knockout
- NF-E2-Related Factor 2 -- drug effects
- Reactive Oxygen Species -- metabolism
- Sequestosome-1 Protein -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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