Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway. [electronic resource]
Producer: 20201009Description: 1274-1282 p. digitalISSN:- 1097-0142
- Aged
- Class I Phosphatidylinositol 3-Kinases
- Class Ia Phosphatidylinositol 3-Kinase -- genetics
- Endometrial Neoplasms -- drug therapy
- Enzyme Activation
- Female
- Humans
- Hyperglycemia -- chemically induced
- Hypoalbuminemia -- chemically induced
- Hypophosphatemia -- chemically induced
- Middle Aged
- Mutation
- PTEN Phosphohydrolase -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Progression-Free Survival
- Proto-Oncogene Proteins c-akt -- genetics
- Pyridines -- adverse effects
- Quinolones -- adverse effects
- Signal Transduction
- TOR Serine-Threonine Kinases
- Treatment Outcome
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Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
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