CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. [electronic resource]
Producer: 20200505Description: 513-521 p. digitalISSN:- 1091-6490
- Animals
- Apoptosis -- genetics
- CRISPR-Cas Systems -- genetics
- Cell Line
- Cell Proliferation -- genetics
- Disease Models, Animal
- Disease Progression
- Feasibility Studies
- Gene Editing -- methods
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Loss of Function Mutation
- Lung -- pathology
- Lung Neoplasms -- genetics
- Mice
- Mice, Transgenic
- Neoplasm Staging
- Retinoblastoma-Like Protein p107 -- genetics
- Retinoblastoma-Like Protein p130 -- genetics
- Small Cell Lung Carcinoma -- genetics
- Tumor Burden -- genetics
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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