Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. [electronic resource]
Producer: 20200406Description: 5795 p. digitalISSN:- 2041-1723
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Arthritis, Experimental -- drug therapy
- Cell Line
- Crystallography, X-Ray
- Drug Discovery
- Male
- Mice
- Molecular Dynamics Simulation
- Neutrophil Infiltration -- drug effects
- Neutrophils -- drug effects
- Protein Multimerization -- drug effects
- Protein Stability -- drug effects
- Protein Structure, Quaternary -- drug effects
- Receptors, Tumor Necrosis Factor, Type I -- immunology
- Recombinant Proteins -- isolation & purification
- Signal Transduction -- drug effects
- Structure-Activity Relationship
- Treatment Outcome
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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