Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells. [electronic resource]
Producer: 20201106Description: 19353 p. digitalISSN:- 2045-2322
- Anaplastic Lymphoma Kinase -- metabolism
- Animals
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation
- Female
- Humans
- Inhibitory Concentration 50
- Macrocyclic Compounds -- pharmacology
- Mice, Inbred BALB C
- Mutation -- genetics
- Neovascularization, Pathologic -- drug therapy
- Neurites -- drug effects
- Neuroblastoma -- blood supply
- PC12 Cells
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Pyrazoles -- pharmacology
- Rats
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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