Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. [electronic resource]
Producer: 20200817Description: 145-158 p. digitalISSN:- 1755-4349
- Animals
- Anti-Bacterial Agents -- chemical synthesis
- Autolysis -- chemically induced
- Benzodioxoles -- chemical synthesis
- Biofilms -- drug effects
- Cell Line, Tumor
- Drug Repositioning
- Female
- Humans
- Male
- Methicillin-Resistant Staphylococcus aureus -- drug effects
- Mice, Inbred C57BL
- Microbial Sensitivity Tests
- Molecular Dynamics Simulation
- Molecular Structure
- Protein Kinase Inhibitors -- chemistry
- Sorafenib -- analogs & derivatives
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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