4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth. [electronic resource]
Producer: 20201111Description: 18455 p. digitalISSN:- 2045-2322
- Animals
- Antineoplastic Agents, Immunological -- chemistry
- Breast Neoplasms -- drug therapy
- Carcinoma, Ehrlich Tumor -- drug therapy
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Enzyme Assays
- Female
- HEK293 Cells
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase -- antagonists & inhibitors
- Inhibitory Concentration 50
- Kynurenine -- immunology
- Metabolic Networks and Pathways -- drug effects
- Mice
- Molecular Docking Simulation
- Primary Cell Culture
- Recombinant Proteins -- chemistry
- T-Lymphocytes, Cytotoxic -- drug effects
- Triazoles -- chemistry
- Tryptophan -- immunology
- Tryptophan Oxygenase -- antagonists & inhibitors
- Tumor Escape -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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