Up-regulation of HDACs, a harbinger of uraemic endothelial dysfunction, is prevented by defibrotide. [electronic resource]
Producer: 20210422Description: 1713-1723 p. digitalISSN:- 1582-4934
- Case-Control Studies
- Cell Nucleus -- drug effects
- Endothelium -- drug effects
- Female
- Histone Deacetylases -- metabolism
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Intercellular Adhesion Molecule-1 -- metabolism
- Male
- Middle Aged
- Phosphatidylinositol 3-Kinases -- metabolism
- Polydeoxyribonucleotides -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Reactive Oxygen Species -- metabolism
- Renal Insufficiency, Chronic -- blood
- Signal Transduction
- Toll-Like Receptor 4 -- metabolism
- Up-Regulation -- drug effects
- Uremia -- blood
- von Willebrand Factor -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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