Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. [electronic resource]
Producer: 20200622Description: 11280-11300 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis
- Azocines -- chemistry
- Cell Proliferation
- Drug Design
- Drug Discovery
- Female
- Humans
- Indoles -- chemistry
- Leukemia, Myeloid, Acute -- drug therapy
- Mice
- Mice, SCID
- Molecular Structure
- Organophosphonates -- chemistry
- Protein Conformation
- Proteolysis -- drug effects
- STAT3 Transcription Factor -- antagonists & inhibitors
- Tissue Distribution
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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