Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis. [electronic resource]
Producer: 20200417Description: 105968 p. digitalISSN:- 1878-1705
- Abietanes -- pharmacology
- Animals
- Bleomycin -- pharmacology
- Cell Line
- Disease Models, Animal
- Endothelial Cells -- drug effects
- Endothelium -- drug effects
- Epithelial-Mesenchymal Transition -- drug effects
- Female
- Fibrosis -- drug therapy
- Human Umbilical Vein Endothelial Cells
- Humans
- Mice
- Mice, Inbred C57BL
- Proto-Oncogene Proteins c-akt -- metabolism
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Salvia miltiorrhiza -- chemistry
- Scleroderma, Systemic -- metabolism
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
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Publication Type: Journal Article
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