Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts. [electronic resource]
Producer: 20200615Description: 14717-14733 p. digitalISSN:- 1530-6860
- Animals
- Cells, Cultured
- Fibrosis
- Humans
- Inflammasomes -- metabolism
- Interleukin-1beta -- metabolism
- Male
- Mice
- Myocardium -- cytology
- Myofibroblasts -- drug effects
- NLR Family, Pyrin Domain-Containing 3 Protein -- metabolism
- Recombinant Proteins -- pharmacology
- Relaxin -- pharmacology
- Toll-Like Receptor 4 -- metabolism
- Transforming Growth Factor beta1 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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