Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib. [electronic resource]
Producer: 20201016Description: 108227 p. digitalISSN:- 1873-4847
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Butadienes -- pharmacology
- Colorectal Neoplasms -- drug therapy
- Curcumin -- administration & dosage
- Gene Expression Regulation, Neoplastic -- drug effects
- HCT116 Cells
- HT29 Cells
- Humans
- MAP Kinase Kinase Kinases -- antagonists & inhibitors
- Mutation
- Nitriles -- pharmacology
- Phenylurea Compounds -- administration & dosage
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins p21(ras) -- genetics
- Pyridines -- administration & dosage
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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