Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling. [electronic resource]
Producer: 20200226Description: 949 p. digitalISSN:- 1471-2407
- A549 Cells
- Alkaloids -- chemistry
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Cell Survival -- drug effects
- Drug Discovery -- methods
- Drugs, Chinese Herbal -- chemistry
- Epithelial-Mesenchymal Transition -- drug effects
- HeLa Cells
- Humans
- MAP Kinase Signaling System
- MCF-7 Cells
- Neoplasms -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Quinolizines -- chemistry
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Sophora -- chemistry
- TOR Serine-Threonine Kinases -- metabolism
- Matrines
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Publication Type: Journal Article
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