Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents. [electronic resource]
Producer: 20201020Description: 103300 p. digitalISSN:- 1090-2120
- Animals
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Binding Sites
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Colchicine -- chemistry
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Kinetics
- Mice
- Molecular Docking Simulation
- Protein Binding
- Protein Structure, Tertiary
- Structure-Activity Relationship
- Triazoles -- chemistry
- Tubulin -- chemistry
- Tubulin Modulators -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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