Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism. [electronic resource]
Producer: 20200402Description: e0222855 p. digitalISSN:- 1932-6203
- Adrenergic alpha-1 Receptor Antagonists -- pharmacology
- Animals
- Antidepressive Agents -- pharmacology
- Dorsal Raphe Nucleus -- cytology
- Dose-Response Relationship, Drug
- Male
- Mice
- Mice, Knockout
- Patch-Clamp Techniques
- Phenylephrine -- pharmacology
- Piperazines -- pharmacology
- Pyridines -- pharmacology
- Rats
- Receptor, Serotonin, 5-HT1A -- metabolism
- Receptors, Adrenergic, alpha-1 -- metabolism
- Serotonergic Neurons -- drug effects
- Serotonin 5-HT1 Receptor Agonists -- pharmacology
- Trazodone -- pharmacology
- Tryptophan Hydroxylase -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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