Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5. [electronic resource]
Producer: 20200316Description: e0222803 p. digitalISSN:- 1932-6203
- Animals
- Biocatalysis -- drug effects
- Cell Line
- Cell Line, Tumor
- Cyclic GMP -- chemistry
- Cyclic Nucleotide Phosphodiesterases, Type 5 -- chemistry
- Erectile Dysfunction -- drug therapy
- Flavonoids -- chemical synthesis
- Humans
- Hypertension, Pulmonary -- drug therapy
- Male
- Models, Chemical
- Molecular Structure
- Phosphodiesterase 5 Inhibitors -- chemical synthesis
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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