Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer. [electronic resource]
Producer: 20200831Description: 2156-2168.e5 p. digitalISSN:- 2211-1247
- Animals
- Carcinogenesis -- metabolism
- Cell Cycle Checkpoints
- Cell Line, Tumor
- Cell Polarity
- Cellular Senescence
- Chemokine CXCL2 -- administration & dosage
- Humans
- Inflammation -- pathology
- Macrophages -- pathology
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Neoplasm Staging
- Neutralization Tests
- PTEN Phosphohydrolase -- metabolism
- Prostatic Neoplasms -- pathology
- Receptors, Interleukin-8B -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Tumor Necrosis Factor-alpha -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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