Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism. [electronic resource]
Producer: 20200309Description: e0220473 p. digitalISSN:- 1932-6203
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid -- pharmacology
- Animals
- Calcium Channel Blockers -- pharmacology
- Calcium Channels -- drug effects
- Disease Models, Animal
- Endothelium, Vascular -- drug effects
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Male
- Muscle Relaxation -- drug effects
- Muscle, Smooth, Vascular -- drug effects
- Nitric Oxide Synthase Type III -- antagonists & inhibitors
- Phenylephrine -- pharmacology
- Pulmonary Arterial Hypertension -- drug therapy
- Pulmonary Artery -- drug effects
- Rats
- Rats, Wistar
- Simvastatin -- pharmacology
- rho-Associated Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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