Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation. [electronic resource]
Producer: 20191017Description: 502-514 p. digitalISSN:- 1768-3254
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Apoptosis -- drug effects
- Cell Cycle Proteins
- Cell Proliferation -- drug effects
- Crystallography, X-Ray
- Dose-Response Relationship, Drug
- Drug Design
- Female
- Humans
- Microsomes, Liver -- chemistry
- Models, Molecular
- Molecular Structure
- Nuclear Proteins -- antagonists & inhibitors
- Phenanthridines -- administration & dosage
- Rats
- Rats, Sprague-Dawley
- Structure-Activity Relationship
- Transcription Factors -- antagonists & inhibitors
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Publication Type: Journal Article
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