Small molecular modulators of JMJD1C preferentially inhibit growth of leukemia cells. [electronic resource]
Producer: 20200219Description: 400-412 p. digitalISSN:- 1097-0215
- Adult
- Aged
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Bone Marrow -- pathology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- DNA Demethylation -- drug effects
- DNA Methylation -- drug effects
- Drug Screening Assays, Antitumor
- Drug Synergism
- Female
- Histones -- metabolism
- Humans
- Jumonji Domain-Containing Histone Demethylases -- antagonists & inhibitors
- Leukemia, Biphenotypic, Acute -- drug therapy
- Male
- Middle Aged
- Molecular Docking Simulation
- Oxidoreductases, N-Demethylating -- antagonists & inhibitors
- Protein Domains
- Structure-Activity Relationship
- Surface Plasmon Resonance
- Tretinoin -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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