Functional interrogation of Lynch syndrome-associated MSH2 missense variants via CRISPR-Cas9 gene editing in human embryonic stem cells. [electronic resource]
Producer: 20200309Description: 2044-2056 p. digitalISSN:- 1098-1004
- CRISPR-Cas Systems
- Cell Line, Tumor
- Colorectal Neoplasms, Hereditary Nonpolyposis -- diagnosis
- DNA Damage
- DNA Repair
- Gene Editing
- High-Throughput Nucleotide Sequencing
- Human Embryonic Stem Cells -- metabolism
- Humans
- Microsatellite Instability
- Models, Molecular
- MutS Homolog 2 Protein -- chemistry
- Mutation, Missense
- Protein Conformation
- Signal Transduction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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