Entinostat combined with Fludarabine synergistically enhances the induction of apoptosis in TP53 mutated CLL cells via the HDAC1/HO-1 pathway. [electronic resource]
Producer: 20190924Description: 116583 p. digitalISSN:- 1879-0631
- Aged
- Aged, 80 and over
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Benzamides -- administration & dosage
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Drug Synergism
- Female
- Heme Oxygenase-1 -- metabolism
- Histone Deacetylase 1 -- biosynthesis
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Male
- Mice
- Mice, Nude
- Middle Aged
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Pyridines -- administration & dosage
- Random Allocation
- Signal Transduction -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Vidarabine -- administration & dosage
- Xenograft Model Antitumor Assays
- bcl-2-Associated X Protein -- biosynthesis
No physical items for this record
Publication Type: Journal Article
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