The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. [electronic resource]
Producer: 20200526Description: 59 p. digitalISSN:- 1756-6606
- Animals
- Base Sequence
- Embryo Loss -- enzymology
- Gene Expression Regulation, Enzymologic
- Gene Knock-In Techniques
- HEK293 Cells
- Hereditary Central Nervous System Demyelinating Diseases -- genetics
- Homozygote
- Humans
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Motor Activity
- Mutation -- genetics
- Myelin Sheath -- metabolism
- RNA Polymerase III -- genetics
- RNA, Messenger -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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