Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. [electronic resource]
Producer: 20190725Description: 414-424 p. digitalISSN:- 1768-3254
- Amyloid beta-Peptides -- metabolism
- Azepines -- chemical synthesis
- Butyrylcholinesterase -- chemistry
- Catalytic Domain
- Cell Line, Tumor
- Cholinesterase Inhibitors -- chemical synthesis
- Dose-Response Relationship, Drug
- Drug Design
- Free Radical Scavengers -- chemical synthesis
- Humans
- Indoles -- chemical synthesis
- Molecular Docking Simulation
- Molecular Structure
- Neuroprotective Agents -- chemical synthesis
- Peptide Fragments -- metabolism
- Protein Binding -- drug effects
- Protein Multimerization -- drug effects
- Structure-Activity Relationship
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Publication Type: Journal Article
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