A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy. [electronic resource]
Producer: 20191218Description: 98-111 p. digitalISSN:- 2352-3964
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line
- Cell Line, Tumor
- Cell Survival -- drug effects
- DNA Damage
- DNA Methylation -- drug effects
- Dose-Response Relationship, Drug
- Drug Discovery
- Enzyme Inhibitors -- chemistry
- Epigenesis, Genetic -- drug effects
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Immunohistochemistry
- Kruppel-Like Factor 4
- Kruppel-Like Transcription Factors -- genetics
- Mice
- Models, Molecular
- Molecular Conformation
- Molecular Targeted Therapy
- Neoplastic Stem Cells -- metabolism
- Protein-Arginine N-Methyltransferases -- antagonists & inhibitors
- Recombinant Fusion Proteins
- Structure-Activity Relationship
- Substrate Specificity
- Triple Negative Breast Neoplasms -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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