Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk. [electronic resource]
Producer: 20190617Description: e12609 p. digitalISSN:- 1365-2184
- Antineoplastic Agents -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor
- Cisplatin -- pharmacology
- Drug Resistance, Neoplasm
- Hep G2 Cells
- Humans
- Liver Neoplasms -- drug therapy
- Lysosomes -- drug effects
- Mitochondria -- drug effects
- Mitochondrial Dynamics -- drug effects
- Mitophagy -- drug effects
- Phenylurea Compounds -- pharmacology
- Phosphoinositide-3 Kinase Inhibitors
- Pyrimidines -- pharmacology
- Reactive Oxygen Species -- metabolism
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
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Publication Type: Journal Article
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