Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. [electronic resource]
Producer: 20200203Description: 664-676.e7 p. digitalISSN:- 1878-3686
- Animals
- Antineoplastic Agents -- pharmacology
- Asparaginase -- pharmacology
- Cell Death -- drug effects
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Glycogen Synthase Kinase 3 beta -- antagonists & inhibitors
- Humans
- Jurkat Cells
- Leukemia -- drug therapy
- Male
- Mice, Inbred NOD
- Mice, Transgenic
- Polyethylene Glycols -- pharmacology
- Proteasome Endopeptidase Complex -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein Stability
- Proteolysis
- Synthetic Lethal Mutations
- THP-1 Cells
- Ubiquitination
- Wnt Signaling Pathway -- genetics
- Wnt3A Protein -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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