Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). [electronic resource]
Producer: 20200303Description: 1420-1442 p. digitalISSN:- 1520-4804
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dipeptides -- chemical synthesis
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Ligands
- Molecular Structure
- Proteolysis
- Pyrrolidines -- chemical synthesis
- Receptors, Estrogen -- chemistry
- Structure-Activity Relationship
- Thiophenes -- chemical synthesis
- Ubiquitin-Protein Ligases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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