Spironolactone dose‑dependently alleviates the calcification of aortic rings cultured in hyperphosphatemic medium with or without hyperglycemia by suppressing phenotypic transition of VSMCs through downregulation of Pit‑1. [electronic resource]
Producer: 20190801Description: 3622-3632 p. digitalISSN:- 1791-3004
- Animals
- Dose-Response Relationship, Drug
- Gene Expression Regulation -- drug effects
- Hyperphosphatemia -- metabolism
- Immunophenotyping
- Male
- Muscle, Smooth, Vascular -- cytology
- Myocytes, Smooth Muscle -- drug effects
- Phenotype
- Rats
- Spironolactone -- pharmacology
- Transcription Factor Pit-1 -- genetics
- Vascular Calcification -- drug therapy
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Publication Type: Journal Article
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