Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription. [electronic resource]
Producer: 20200207Description: 2195-2207 p. digitalISSN:- 1538-7445
- Animals
- Apoptosis
- Biomarkers, Tumor -- genetics
- Calcium -- metabolism
- Cell Proliferation
- Colorectal Neoplasms -- drug therapy
- Drug Synergism
- Drug Therapy, Combination
- Enzyme Inhibitors -- pharmacology
- ErbB Receptors -- antagonists & inhibitors
- Female
- Gefitinib -- pharmacology
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Inositol 1,4,5-Trisphosphate Receptors -- genetics
- Mice
- Mice, Nude
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins -- antagonists & inhibitors
- S-Phase Kinase-Associated Proteins -- antagonists & inhibitors
- Thapsigargin -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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